5SUN
IDH1 R132H in complex with IDH146
Summary for 5SUN
Entry DOI | 10.2210/pdb5sun/pdb |
Related | 5SVF 5SVN 5SVO |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-benzyl-N-[3-(dimethylsulfamoyl)phenyl]-4-oxo-3,4-dihydrophthalazine-1-carboxamide, ... (7 entities in total) |
Functional Keywords | inhibitor, isocitrate dehydrogenase, nadph, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : O75874 |
Total number of polymer chains | 2 |
Total formula weight | 96905.32 |
Authors | Xie, X.,Kulathila, R. (deposition date: 2016-08-03, release date: 2017-02-08, Last modification date: 2024-03-06) |
Primary citation | Xie, X.,Baird, D.,Bowen, K.,Capka, V.,Chen, J.,Chenail, G.,Cho, Y.,Dooley, J.,Farsidjani, A.,Fortin, P.,Kohls, D.,Kulathila, R.,Lin, F.,McKay, D.,Rodrigues, L.,Sage, D.,Toure, B.B.,van der Plas, S.,Wright, K.,Xu, M.,Yin, H.,Levell, J.,Pagliarini, R.A. Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25:506-513, 2017 Cited by PubMed: 28132785DOI: 10.1016/j.str.2016.12.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.477 Å) |
Structure validation
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