5SUN

IDH1 R132H in complex with IDH146

Summary for 5SUN

• Entry DOI: 10.2210/pdb5sun/pdb
• Related: 5SVF 5SVN 5SVO
• Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-benzyl-N-[3-(dimethylsulfamoyl)phenyl]-4-oxo-3,4-dihydrophthalazine-1-carboxamide, ... (7 entities in total)
• Functional Keywords: inhibitor, isocitrate dehydrogenase, nadph, oxidoreductase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : O75874
• Total number of polymer chains: 2
• Total formula weight: 96905.32

Authors

Xie, X.,Kulathila, R. (deposition date: 2016-08-03, release date: 2017-02-08, Last modification date: 2024-03-06)

• Primary citation: Xie, X.,Baird, D.,Bowen, K.,Capka, V.,Chen, J.,Chenail, G.,Cho, Y.,Dooley, J.,Farsidjani, A.,Fortin, P.,Kohls, D.,Kulathila, R.,Lin, F.,McKay, D.,Rodrigues, L.,Sage, D.,Toure, B.B.,van der Plas, S.,Wright, K.,Xu, M.,Yin, H.,Levell, J.,Pagliarini, R.A.; Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.; Structure, 25:506-513, 2017; PubMed: 28132785; DOI: 10.1016/j.str.2016.12.017

Experimental method

X-RAY DIFFRACTION (2.477 Å)