5SFE
Crystal Structure of human phosphodiesterase 10 in complex with 3-N-[2-(3-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-4-N,4-N,2-trimethylpyrazole-3,4-dicarboxamide
Summary for 5SFE
Entry DOI | 10.2210/pdb5sfe/pdb |
Group deposition | Exploiting Structural Data for Improved On-Target Prediction in Lead Optimization (G_1002226) |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 159641.27 |
Authors | Joseph, C.,Gobbi, L.,Benz, J.,Schlatter, D.,Rudolph, M.G. (deposition date: 2022-01-21, release date: 2022-10-19, Last modification date: 2024-04-03) |
Primary citation | Gobbi, L.,Benz, J.,Schlatter, D.,Rudolph, M.G. Crystal Structure of a human phosphodiesterase 10 complex To be published, |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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