5SFE

Crystal Structure of human phosphodiesterase 10 in complex with 3-N-[2-(3-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-4-N,4-N,2-trimethylpyrazole-3,4-dicarboxamide

5SFE の概要

• エントリーDOI: 10.2210/pdb5sfe/pdb
• Group deposition: Exploiting Structural Data for Improved On-Target Prediction in Lead Optimization (G_1002226)
• 分子名称: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: phosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 159641.27

構造登録者

Joseph, C.,Gobbi, L.,Benz, J.,Schlatter, D.,Rudolph, M.G. (登録日: 2022-01-21, 公開日: 2022-10-19, 最終更新日: 2024-04-03)

• 主引用文献: Gobbi, L.,Benz, J.,Schlatter, D.,Rudolph, M.G.; Crystal Structure of a human phosphodiesterase 10 complex; To be published,

実験手法

X-RAY DIFFRACTION (1.86 Å)