5SCI

Structure of liver pyruvate kinase in complex with anthraquinone derivative 105

5SCI の概要

• エントリーDOI: 10.2210/pdb5sci/pdb
• Group deposition: ADP-competitive inhibitors of PKL (G_1002224)
• 分子名称: Pyruvate kinase, 1,6-di-O-phosphono-beta-D-fructofuranose, OXALATE ION, ... (7 entities in total)
• 機能のキーワード: pyruvate kinase, active site, inhibition, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 392513.56

構造登録者

Lulla, A.,Foller, A.,Nain-Perez, A.,Grotli, M.,Brear, P.,Hyvonen, M. (登録日: 2021-12-01, 公開日: 2022-03-16, 最終更新日: 2024-05-22)

• 主引用文献: Nain-Perez, A.,Foller Fuchtbauer, A.,Haversen, L.,Lulla, A.,Gao, C.,Matic, J.,Monjas, L.,Rodriguez, A.,Brear, P.,Kim, W.,Hyvonen, M.,Boren, J.,Mardinoglu, A.,Uhlen, M.,Grotli, M.; Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.; Eur.J.Med.Chem., 234:114270-114270, 2022; PubMed: 35290845; DOI: 10.1016/j.ejmech.2022.114270

実験手法

X-RAY DIFFRACTION (2.155 Å)