5SB2

DDR1, 3-chloro-N-[(1R,2S)-2-phenylcyclopropyl]-5-(1H-pyrrolo[2,3-b]pyridin-5-yloxymethyl)benzamide, 1.600A, P212121, Rfree=23.2%

5SB2 の概要

• エントリーDOI: 10.2210/pdb5sb2/pdb
• Group deposition: Novel Potent and Highly Selective DDR1 Inhibitors from Structure-guided Drug Design (G_1002213)
• 分子名称: Epithelial discoidin domain-containing receptor 1, IODIDE ION, 3-chloro-N-[(1R,2S)-2-phenylcyclopropyl]-5-{[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]methyl}benzamide, ... (4 entities in total)
• 機能のキーワード: rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37555.26

構造登録者

Stihle, M.,Richter, H.,Benz, J.,Kocer, B.,Hochstrasser, R.,Rudolph, M.G. (登録日: 2021-06-22, 公開日: 2022-06-29, 最終更新日: 2024-04-03)

• 主引用文献: Richter, H.,Prunotto, M.,Kuhn, B.,Rudolph, M.G.; Crystal Structure of a DDR1 complex; To be published,

実験手法

X-RAY DIFFRACTION (1.6 Å)