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5SB0

DDR1, N-[[2-(2-pyridin-3-yloxyethyl)cyclohexyl]methyl]-3-(trifluoromethoxy)benzamide, 1.970A, P212121, Rfree=25.6%

Summary for 5SB0
Entry DOI10.2210/pdb5sb0/pdb
Group depositionNovel Potent and Highly Selective DDR1 Inhibitors from Structure-guided Drug Design (G_1002213)
DescriptorEpithelial discoidin domain-containing receptor 1, IODIDE ION, N-{[(1R,2S)-2-{2-[(pyridin-3-yl)oxy]ethyl}cyclohexyl]methyl}-3-(trifluoromethoxy)benzamide, ... (5 entities in total)
Functional Keywordsrtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight37087.65
Authors
Stihle, M.,Richter, H.,Benz, J.,Hochstrasser, R.,Rudolph, M.G. (deposition date: 2021-06-22, release date: 2022-06-29, Last modification date: 2024-04-03)
Primary citationRichter, H.,Prunotto, M.,Kuhn, B.,Rudolph, M.G.
Crystal Structure of a DDR1 complex
To be published,
Experimental method
X-RAY DIFFRACTION (1.97 Å)
Structure validation

221051

건을2024-06-12부터공개중

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