5RW8

INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z28290384

5RW8 の概要

• エントリーDOI: 10.2210/pdb5rw8/pdb
• Group deposition: INPP5D PanDDA analysis group deposition (G_1002180)
• 分子名称: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, N-(2-fluorophenyl)-3-methoxybenzamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: sgc - diamond i04-1 fragment screening, pandda, xchemexplorer, ship1, alzheimers, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53357.22

構造登録者

Bradshaw, W.J.,Newman, J.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gileadi, O. (登録日: 2020-10-30, 公開日: 2020-11-11, 最終更新日: 2024-02-14)

• 主引用文献: Bradshaw, W.J.,Kennedy, E.C.,Moreira, T.,Smith, L.A.,Chalk, R.,Katis, V.L.,Benesch, J.L.P.,Brennan, P.E.,Murphy, E.J.,Gileadi, O.; Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.; Structure, 2024; PubMed: 38309262; DOI: 10.1016/j.str.2024.01.005

実験手法

X-RAY DIFFRACTION (1.27 Å)