5QU1

Crystal Structure of the monomeric human Nck SH3.1 domain, triclinic, 1.08A

Summary for 5QU1

Entry DOI	10.2210/pdb5qu1/pdb
Group deposition	structural plasticity of the Nck1-SH3.1 domain (G_1002110)
Descriptor	Cytoplasmic protein NCK1, SULFATE ION (3 entities in total)
Functional Keywords	sh3 domain, adaptor, peptide binding, signaling protein, domain swap
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	19725.81
Authors	Burger, D.,Ruf, A.,Benz, J.,Schlatter, D.,Rudolph, M.G. (deposition date: 2019-12-13, release date: 2020-02-12, Last modification date: 2024-04-03)
Primary citation	Richter, K.,Rufer, A.C.,Muller, M.,Burger, D.,Casagrande, F.,Grossenbacher, T.,Huber, S.,Hug, M.N.,Koldewey, P.,D'Osualdo, A.,Schlatter, D.,Stoll, T.,Rudolph, M.G. Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295:7849-7864, 2020 Cited by PubMed: 32317279 DOI: 10.1074/jbc.RA120.012788 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.08 Å)

Structure validation