5QC6

Crystal structure of human Cathepsin-S with bound ligand

Summary for 5QC6

• Entry DOI: 10.2210/pdb5qc6/pdb
• Group deposition: Ligand binding to Cathepsin S (G_1002040)
• Descriptor: Cathepsin S, (4~{S})-1-[1-[(2~{S})-3-[3-[3-[2-(4-methylpiperidin-1-yl)ethylsulfanyl]-4-(trifluoromethyl)phenyl]-5-methylsulfonyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-1-yl]-2-oxidanyl-propyl]piperidin-4-yl]-4-oxidanyl-pyrrolidin-2-one (3 entities in total)
• Functional Keywords: d3r, cathepsin s, ligand docking, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 50518.77

Authors

Bembenek, S.D.,Ameriks, M.K.,Mirzadegan, T.,Yang, H.,Shao, C.,Burley, S.K. (deposition date: 2017-08-04, release date: 2017-12-20, Last modification date: 2021-11-17)

• Primary citation: Bembenek, S.D.,Ameriks, M.K.,Mirzadegan, T.,Yang, H.,Shao, C.,Burley, S.K.; Crystal structure of human Cathepsin-S with bound ligand; To be published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)