5QC6

Crystal structure of human Cathepsin-S with bound ligand

5QC6 の概要

• エントリーDOI: 10.2210/pdb5qc6/pdb
• Group deposition: Ligand binding to Cathepsin S (G_1002040)
• 分子名称: Cathepsin S, (4~{S})-1-[1-[(2~{S})-3-[3-[3-[2-(4-methylpiperidin-1-yl)ethylsulfanyl]-4-(trifluoromethyl)phenyl]-5-methylsulfonyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-1-yl]-2-oxidanyl-propyl]piperidin-4-yl]-4-oxidanyl-pyrrolidin-2-one (3 entities in total)
• 機能のキーワード: d3r, cathepsin s, ligand docking, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50518.77

構造登録者

Bembenek, S.D.,Ameriks, M.K.,Mirzadegan, T.,Yang, H.,Shao, C.,Burley, S.K. (登録日: 2017-08-04, 公開日: 2017-12-20, 最終更新日: 2021-11-17)

• 主引用文献: Bembenek, S.D.,Ameriks, M.K.,Mirzadegan, T.,Yang, H.,Shao, C.,Burley, S.K.; Crystal structure of human Cathepsin-S with bound ligand; To be published,

実験手法

X-RAY DIFFRACTION (2.1 Å)