5Q04
Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-5-chlorothiophen-2-yl)sulfonyl-3-(5-bromo-1,3-thiazol-2-yl)urea
Summary for 5Q04
Entry DOI | 10.2210/pdb5q04/pdb |
Group deposition | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with allosteric inhibitors (G_1002030) |
Descriptor | Fructose-1,6-bisphosphatase 1, 4-bromo-N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-chlorothiophene-2-sulfonamide (3 entities in total) |
Functional Keywords | d3r docking, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 298728.08 |
Authors | Ruf, A.,Joseph, C.,Alker, A.,Banner, D.,Tetaz, T.,Benz, J.,Kuhn, B.,Rudolph, M.G.,Yang, H.,Shao, C.,Burley, S.K. (deposition date: 2017-04-18, release date: 2019-01-09, Last modification date: 2024-03-06) |
Primary citation | Ruf, A.,Joseph, C.,Alker, A.,Banner, D.,Tetaz, T.,Benz, J.,Kuhn, B.,Rudolph, M.G. Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-5-chlorothiophen-2-yl)sulfonyl-3-(5-bromo-1,3-thiazol-2-yl)urea To be published, |
Experimental method | X-RAY DIFFRACTION (2.502 Å) |
Structure validation
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