5P9S

humanized rat COMT in complex with 8-hydroxy-6-[3-methyl-5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl]-3H-quinazolin-4-one

Summary for 5P9S

• Entry DOI: 10.2210/pdb5p9s/pdb
• Group deposition: Crystal Structure of COMT complex (G_1002014)
• Descriptor: Catechol O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: methyltransferase, neurotransmitter degradation, transferase
• Biological source: Rattus norvegicus (Rat)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• Total number of polymer chains: 1
• Total formula weight: 25487.50

Authors

Ehler, A.,Jakob-Roetne, R.,Rudolph, M.G. (deposition date: 2016-10-19, release date: 2017-11-22, Last modification date: 2024-04-03)

• Primary citation: Lerner, C.,Jakob-Roetne, R.,Groebke-Zbinden, K.,Buettelmann, B.,Rudolph, M.G.; Crystal Structure of a COMT complex; To be published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)