5P9M

BTK1 BINDS COVALENTLY TO HY-15771 ONO-4059

Summary for 5P9M

Entry DOI	10.2210/pdb5p9m/pdb
Group deposition	Crystal structures of Tyrosine-protein kinase BTK in complex with inhibitors (G_1002011)
Descriptor	Tyrosine-protein kinase BTK, 6-azanyl-9-[(3~{R})-1-[(~{E})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	kinase, kinase-ligand complex, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q06187
Total number of polymer chains	1
Total formula weight	32860.70
Authors	Gardberg, A.S. (deposition date: 2016-09-20, release date: 2017-05-24, Last modification date: 2021-11-17)
Primary citation	Bender, A.T.,Gardberg, A.,Pereira, A.,Johnson, T.,Wu, Y.,Grenningloh, R.,Head, J.,Morandi, F.,Haselmayer, P.,Liu-Bujalski, L. Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling. Mol. Pharmacol., 91:208-219, 2017 Cited by PubMed: 28062735 DOI: 10.1124/mol.116.107037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.41 Å)

Structure validation