5P9F

BTK IN COMPLEX WITH GDC-0834

5P9F の概要

• エントリーDOI: 10.2210/pdb5p9f/pdb
• Group deposition: Crystal structures of Tyrosine-protein kinase BTK in complex with inhibitors (G_1002011)
• 分子名称: Tyrosine-protein kinase BTK, N-{3-[6-({4-[(2R)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl }-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: lead optimization, protein kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q06187
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33263.18

構造登録者

Gardberg, A.S. (登録日: 2016-09-20, 公開日: 2017-05-24, 最終更新日: 2021-11-17)

• 主引用文献: Bender, A.T.,Gardberg, A.,Pereira, A.,Johnson, T.,Wu, Y.,Grenningloh, R.,Head, J.,Morandi, F.,Haselmayer, P.,Liu-Bujalski, L.; Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling.; Mol. Pharmacol., 91:208-219, 2017; PubMed: 28062735; DOI: 10.1124/mol.116.107037

実験手法

X-RAY DIFFRACTION (1.71 Å)