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5OXG

Crystal structure of the ACVR1 (ALK2) kinase in complex with LDN-212854

Summary for 5OXG
Entry DOI10.2210/pdb5oxg/pdb
DescriptorActivin receptor type-1, 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, CALCIUM ION, ... (5 entities in total)
Functional Keywordskinase, alk2, receptor, bmp, structural genomics, structural genomics consortium, sgc, signaling protein
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein: Q04771
Total number of polymer chains4
Total formula weight140079.00
Authors
Primary citationWilliams, E.,Bullock, A.N.
Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2.
Bone, 109:251-258, 2018
Cited by
PubMed: 28918311
DOI: 10.1016/j.bone.2017.09.004
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.13 Å)
Structure validation

217705

數據於2024-03-27公開中

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