5OXG
Crystal structure of the ACVR1 (ALK2) kinase in complex with LDN-212854
Summary for 5OXG
Entry DOI | 10.2210/pdb5oxg/pdb |
Descriptor | Activin receptor type-1, 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | kinase, alk2, receptor, bmp, structural genomics, structural genomics consortium, sgc, signaling protein |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein: Q04771 |
Total number of polymer chains | 4 |
Total formula weight | 140079.00 |
Authors | Williams, E.P.,Sorrell, F.J.,Kopec, J.,Nowak, R.P.,Kupinska, K.,von Delft, F.,Burgess-Brown, N.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N.,Structural Genomics Consortium (SGC) (deposition date: 2017-09-06, release date: 2017-09-20, Last modification date: 2024-01-17) |
Primary citation | Williams, E.,Bullock, A.N. Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2. Bone, 109:251-258, 2018 Cited by PubMed: 28918311DOI: 10.1016/j.bone.2017.09.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.13 Å) |
Structure validation
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