5OXG

Crystal structure of the ACVR1 (ALK2) kinase in complex with LDN-212854

5OXG の概要

• エントリーDOI: 10.2210/pdb5oxg/pdb
• 分子名称: Activin receptor type-1, 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: kinase, alk2, receptor, bmp, structural genomics, structural genomics consortium, sgc, signaling protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: Q04771
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 140079.00

構造登録者

Williams, E.P.,Sorrell, F.J.,Kopec, J.,Nowak, R.P.,Kupinska, K.,von Delft, F.,Burgess-Brown, N.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N.,Structural Genomics Consortium (SGC) (登録日: 2017-09-06, 公開日: 2017-09-20, 最終更新日: 2024-01-17)

• 主引用文献: Williams, E.,Bullock, A.N.; Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2.; Bone, 109:251-258, 2018; PubMed: 28918311; DOI: 10.1016/j.bone.2017.09.004

実験手法

X-RAY DIFFRACTION (2.13 Å)