5OWK
Crystal structure of CREBBP bromodomain complexed with DSPB2A002
Summary for 5OWK
| Entry DOI | 10.2210/pdb5owk/pdb |
| Descriptor | CREB-binding protein, ethyl 4-chloranyl-1-methyl-6-oxidanylidene-pyridine-3-carboxylate (3 entities in total) |
| Functional Keywords | crebbp bromodomain, inhibitor, transcription |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 14654.62 |
| Authors | Zhu, J.,Spiliotopoulos, D.,Caflisch, A. (deposition date: 2017-09-01, release date: 2018-08-29, Last modification date: 2024-01-17) |
| Primary citation | Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9:929-934, 2018 Cited by PubMed: 30258543DOI: 10.1021/acsmedchemlett.8b00286 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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