5OWC

Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors

Summary for 5OWC

• Entry DOI: 10.2210/pdb5owc/pdb
• Related: 5OW8
• Descriptor: Group 10 secretory phospholipase A2, CALCIUM ION, 3-[3-[2-aminocarbonyl-6-(trifluoromethyloxy)indol-1-yl]phenyl]propanoic acid, ... (6 entities in total)
• Functional Keywords: inhibitor, secreted, phospholipase, lipid binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 28872.96

Authors

Sandmark, J.S.,Roth, R.G.,Knerr, L.,Bodin, C.,Pettersen, D. (deposition date: 2017-08-31, release date: 2018-08-01, Last modification date: 2021-05-05)

• Primary citation: Knerr, L.,Giordanetto, F.,Nordberg, P.,Pettersen, D.,Selmi, N.,Beisel, H.G.,de la Motte, H.,Olsson, T.,Perkins, T.D.J.,Herslof, M.,Mansson, A.,Dahlstrom, M.,Starke, I.,Broddefalk, J.,Saarinen, G.,Klingegard, F.,Hurt-Camejo, E.,Rosengren, B.,Brengdahl, J.,Jansen, F.,Rohman, M.,Sandmark, J.,Hallberg, K.,Akerud, T.,Roth, R.G.,Ahlqvist, M.; Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2Type X (sPLA2-X) Inhibitors.; Acs Med.Chem.Lett., 9:594-599, 2018; PubMed: 30034585; DOI: 10.1021/acsmedchemlett.7b00505

Experimental method

X-RAY DIFFRACTION (1.75 Å)