5OV7

tubulin - rigosertib complex

Summary for 5OV7

Entry DOI	10.2210/pdb5ov7/pdb
Descriptor	Tubulin alpha-1B chain, N-[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (13 entities in total)
Functional Keywords	cell cycle, tubulin fold, cytoskeleton, microtubule
Biological source	Rattus norvegicus (Norway Rat) More
Cellular location	Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043
Total number of polymer chains	6
Total formula weight	265881.68
Authors	Menchon, G.,Prota, A.E.,Steinmetz, M.,Jost, M. (deposition date: 2017-08-28, release date: 2017-10-11, Last modification date: 2024-01-17)
Primary citation	Jost, M.,Chen, Y.,Gilbert, L.A.,Horlbeck, M.A.,Krenning, L.,Menchon, G.,Rai, A.,Cho, M.Y.,Stern, J.J.,Prota, A.E.,Kampmann, M.,Akhmanova, A.,Steinmetz, M.O.,Tanenbaum, M.E.,Weissman, J.S. Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol. Cell, 68:210-223.e6, 2017 Cited by PubMed: 28985505 DOI: 10.1016/j.molcel.2017.09.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.402 Å)

Structure validation