5OV7
tubulin - rigosertib complex
Summary for 5OV7
Entry DOI | 10.2210/pdb5ov7/pdb |
Descriptor | Tubulin alpha-1B chain, N-[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (13 entities in total) |
Functional Keywords | cell cycle, tubulin fold, cytoskeleton, microtubule |
Biological source | Rattus norvegicus (Norway Rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265881.68 |
Authors | Menchon, G.,Prota, A.E.,Steinmetz, M.,Jost, M. (deposition date: 2017-08-28, release date: 2017-10-11, Last modification date: 2024-01-17) |
Primary citation | Jost, M.,Chen, Y.,Gilbert, L.A.,Horlbeck, M.A.,Krenning, L.,Menchon, G.,Rai, A.,Cho, M.Y.,Stern, J.J.,Prota, A.E.,Kampmann, M.,Akhmanova, A.,Steinmetz, M.O.,Tanenbaum, M.E.,Weissman, J.S. Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol. Cell, 68:210-223.e6, 2017 Cited by PubMed: 28985505DOI: 10.1016/j.molcel.2017.09.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.402 Å) |
Structure validation
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