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5OTN

Crystal structure of zebrafish MTH1 in complex with O6-methyl-dGMP

Summary for 5OTN
Entry DOI10.2210/pdb5otn/pdb
Related5OTM
DescriptorNudix (Nucleoside diphosphate linked moiety X)-type motif 1, 6-O-METHYL GUANOSINE-5'-MONOPHOSPHATE, GLYCEROL, ... (7 entities in total)
Functional Keywordsmth1, inhibitor, complex, hydrolase, nudix, methylated nucleotide, o6-methyl-dgmp, zebrafish
Biological sourceDanio rerio (Zebrafish)
Total number of polymer chains1
Total formula weight19858.98
Authors
Gustafsson, R.,Henriksson, L.,Jemth, A.-S.,Brautigam, L.,Carreras Puigvert, J.,Homan, E.,Warpman Berglund, U.,Helleday, T.,Stenmark, P. (deposition date: 2017-08-22, release date: 2018-09-05, Last modification date: 2024-01-17)
Primary citationJemth, A.S.,Gustafsson, R.,Brautigam, L.,Henriksson, L.,Vallin, K.S.A.,Sarno, A.,Almlof, I.,Homan, E.,Rasti, A.,Warpman Berglund, U.,Stenmark, P.,Helleday, T.
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Nucleic Acids Res., 46:10888-10904, 2018
Cited by
PubMed: 30304478
DOI: 10.1093/nar/gky896
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (0.99 Å)
Structure validation

221051

数据于2024-06-12公开中

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