5OTF
MRCK beta in complex with BDP-00009066
Summary for 5OTF
Entry DOI | 10.2210/pdb5otf/pdb |
Descriptor | Serine/threonine-protein kinase MRCK beta, CHLORIDE ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | myotonic dystrophy kinase-related cdc42-binding kinase, metastasis, cell invasion, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q9Y5S2 |
Total number of polymer chains | 1 |
Total formula weight | 48531.40 |
Authors | Schuettelkopf, A.W. (deposition date: 2017-08-21, release date: 2018-02-21, Last modification date: 2024-01-17) |
Primary citation | Unbekandt, M.,Belshaw, S.,Bower, J.,Clarke, M.,Cordes, J.,Crighton, D.,Croft, D.R.,Drysdale, M.J.,Garnett, M.J.,Gill, K.,Gray, C.,Greenhalgh, D.A.,Hall, J.A.M.,Konczal, J.,Lilla, S.,McArthur, D.,McConnell, P.,McDonald, L.,McGarry, L.,McKinnon, H.,McMenemy, C.,Mezna, M.,Morrice, N.A.,Munro, J.,Naylor, G.,Rath, N.,Schuttelkopf, A.W.,Sime, M.,Olson, M.F. Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. Cancer Res., 78:2096-2114, 2018 Cited by PubMed: 29382705DOI: 10.1158/0008-5472.CAN-17-2870 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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