5OSK
Tubulin-7j complex
Summary for 5OSK
Entry DOI | 10.2210/pdb5osk/pdb |
Descriptor | Tubulin alpha-1B chain, 3-(2,5-Dimethoxybenzyl)-7-sulfamoyloxy-6-methoxy-3,4-dihydroquinazolin-2(1H)-one, CALCIUM ION, ... (14 entities in total) |
Functional Keywords | cell cycle, tubulin fold, cytoskeleton, microtubule quinazolinones |
Biological source | Rattus norvegicus (Norway rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265632.40 |
Authors | Menchon, G.,Prota, A.E.,Steinmetz, M.O.,Potter, B.V.L. (deposition date: 2017-08-17, release date: 2017-12-20, Last modification date: 2024-01-17) |
Primary citation | Dohle, W.,Jourdan, F.L.,Menchon, G.,Prota, A.E.,Foster, P.A.,Mannion, P.,Hamel, E.,Thomas, M.P.,Kasprzyk, P.G.,Ferrandis, E.,Steinmetz, M.O.,Leese, M.P.,Potter, B.V.L. Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure. J. Med. Chem., 61:1031-1044, 2018 Cited by PubMed: 29227648DOI: 10.1021/acs.jmedchem.7b01474 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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