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5ORL

Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment

Summary for 5ORL
Entry DOI10.2210/pdb5orl/pdb
DescriptorAurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordskinase, allosteric inhibitor, fragment, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
Total number of polymer chains1
Total formula weight31614.10
Authors
Primary citationMcIntyre, P.J.,Collins, P.M.,Vrzal, L.,Birchall, K.,Arnold, L.H.,Mpamhanga, C.,Coombs, P.J.,Burgess, S.G.,Richards, M.W.,Winter, A.,Veverka, V.,Delft, F.V.,Merritt, A.,Bayliss, R.
Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12:2906-2914, 2017
Cited by
PubMed: 29045126
DOI: 10.1021/acschembio.7b00537
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.69 Å)
Structure validation

217705

건을2024-03-27부터공개중

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