5OQW

XIAP in complex with small molecule

5OQW の概要

• エントリーDOI: 10.2210/pdb5oqw/pdb
• 分子名称: E3 ubiquitin-protein ligase XIAP, ZINC ION, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: xiap, protease inhibitor, apoptosis regulation, apoptosis
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30385.79

構造登録者

Williams, P.A. (登録日: 2017-08-14, 公開日: 2018-06-27, 最終更新日: 2024-05-08)

• 主引用文献: Ward, G.A.,Lewis, E.J.,Ahn, J.S.,Johnson, C.N.,Lyons, J.F.,Martins, V.,Munck, J.M.,Rich, S.J.,Smyth, T.,Thompson, N.T.,Williams, P.A.,Wilsher, N.E.,Wallis, N.G.,Chessari, G.; ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNF alpha-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth.; Mol. Cancer Ther., 17:1381-1391, 2018; PubMed: 29695633; DOI: 10.1158/1535-7163.MCT-17-0848

実験手法

X-RAY DIFFRACTION (2.31 Å)