5OPL

Crystal structure of K25E cN-II mutant

Summary for 5OPL

• Entry DOI: 10.2210/pdb5opl/pdb
• Related: 5opl
• Descriptor: Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: nucleotidase, relapsed leukemia, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 64942.02

Authors

Kugler, M.,Hnizda, A.,Pachl, P.,Rezacova, P. (deposition date: 2017-08-10, release date: 2018-06-13, Last modification date: 2018-06-20)

• Primary citation: Hnizda, A.,Fabry, M.,Moriyama, T.,Pachl, P.,Kugler, M.,Brinsa, V.,Ascher, D.B.,Carroll, W.L.,Novak, P.,Zaliova, M.,Trka, J.,Rezacova, P.,Yang, J.J.,Veverka, V.; Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.; Leukemia, 32:1393-1403, 2018; PubMed: 29535428; DOI: 10.1038/s41375-018-0073-5

Experimental method

X-RAY DIFFRACTION (1.8 Å)