5OOI

STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P

Summary for 5OOI

• Entry DOI: 10.2210/pdb5ooi/pdb
• Related: 5OMY 5ONI
• Descriptor: Casein kinase II subunit alpha', 4-(3-methylbut-2-enoxy)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: protein kinase ck2, casein kinase 2, indenoindole-type inhibitors, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 86932.00

Authors

Hochscherf, J.,Lindenblatt, D.,Witulski, B.,Birus, R.,Aichele, D.,Marminon, C.,Bouaziz, Z.,Le Borgne, M.,Jose, J.,Niefind, K. (deposition date: 2017-08-07, release date: 2017-12-27, Last modification date: 2024-01-17)

• Primary citation: Hochscherf, J.,Lindenblatt, D.,Witulski, B.,Birus, R.,Aichele, D.,Marminon, C.,Bouaziz, Z.,Le Borgne, M.,Jose, J.,Niefind, K.; Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2 alpha and Its Paralog CK2 alpha '.; Pharmaceuticals (Basel), 10:-, 2017; PubMed: 29236079; DOI: 10.3390/ph10040098

Experimental method

X-RAY DIFFRACTION (1.998 Å)