5OMY

HIGH-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P

5OMY の概要

• エントリーDOI: 10.2210/pdb5omy/pdb
• 分子名称: Casein kinase II subunit alpha, 4-(3-methylbut-2-enoxy)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: protein kinase ck2, casein kinase 2, indenoindole-type inhibitors, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P68400
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45749.27

構造登録者

Hochscherf, J.,Lindenblatt, D.,Witulski, B.,Birus, R.,Aichele, D.,Marminon, C.,Bouaziz, Z.,Le Borgne, M.,Jose, J.,Niefind, K. (登録日: 2017-08-02, 公開日: 2017-12-27, 最終更新日: 2024-01-17)

• 主引用文献: Hochscherf, J.,Lindenblatt, D.,Witulski, B.,Birus, R.,Aichele, D.,Marminon, C.,Bouaziz, Z.,Le Borgne, M.,Jose, J.,Niefind, K.; Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2 alpha and Its Paralog CK2 alpha '.; Pharmaceuticals (Basel), 10:-, 2017; PubMed: 29236079; DOI: 10.3390/ph10040098

実験手法

X-RAY DIFFRACTION (1.95 Å)