5OMG

p38alpha in complex with pyrazolobenzothiazine inhibitor COXP4M12

5OMG の概要

• エントリーDOI: 10.2210/pdb5omg/pdb
• 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 3-(4-fluorophenyl)-4-methyl-1~{H}-pyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide, ... (4 entities in total)
• 機能のキーワード: p38, kinase, inhibitor, pyrazolobenzothiazine, complex, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41964.91

構造登録者

Buehrmann, M.,Rauh, D. (登録日: 2017-07-31, 公開日: 2019-03-13, 最終更新日: 2020-07-29)

• 主引用文献: Bartolini, D.,Buhrmann, M.,Barreca, M.L.,Manfroni, G.,Cecchetti, V.,Rauh, D.,Galli, F.; Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38 alpha MAPK inhibitors.; Biochem.Biophys.Res.Commun., 511:579-586, 2019; PubMed: 30824186; DOI: 10.1016/j.bbrc.2019.02.063

実験手法

X-RAY DIFFRACTION (2 Å)