5OM5
Crystal structure of Alpha1-antichymotrypsin variant DBS-I-allo1: an allosterically triggered drug-binding serpin for doxycycline
Summary for 5OM5
Entry DOI | 10.2210/pdb5om5/pdb |
Descriptor | Alpha-1-antichymotrypsin, 1,2-ETHANEDIOL, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | serpin, alpha1-antichymotrypsin, doxycycline-binding protein, allosterically triggered drug release, transport protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 46938.77 |
Authors | Schmidt, K.,Muller, Y.A. (deposition date: 2017-07-28, release date: 2018-05-23, Last modification date: 2024-05-08) |
Primary citation | Schmidt, K.,Gardill, B.R.,Kern, A.,Kirchweger, P.,Borsch, M.,Muller, Y.A. Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115:5744-5749, 2018 Cited by PubMed: 29760101DOI: 10.1073/pnas.1716666115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.595 Å) |
Structure validation
Download full validation report