5OM5

Crystal structure of Alpha1-antichymotrypsin variant DBS-I-allo1: an allosterically triggered drug-binding serpin for doxycycline

Summary for 5OM5

Entry DOI	10.2210/pdb5om5/pdb
Descriptor	Alpha-1-antichymotrypsin, 1,2-ETHANEDIOL, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	serpin, alpha1-antichymotrypsin, doxycycline-binding protein, allosterically triggered drug release, transport protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	46938.77
Authors	Schmidt, K.,Muller, Y.A. (deposition date: 2017-07-28, release date: 2018-05-23, Last modification date: 2024-05-08)
Primary citation	Schmidt, K.,Gardill, B.R.,Kern, A.,Kirchweger, P.,Borsch, M.,Muller, Y.A. Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115:5744-5749, 2018 Cited by PubMed: 29760101 DOI: 10.1073/pnas.1716666115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.595 Å)

Structure validation