5OH7

Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Imidazolidine-2,4-dione (Hydantoin)

Summary for 5OH7

DescriptorCereblon isoform 4, ZINC ION, imidazolidine-2,4-dione, ... (4 entities in total)
Functional Keywordsteratogenicity, protein degradation, substrate recognition, ubiquitin ligase, unknown function
Biological sourceMagnetospirillum gryphiswaldense
Total number of polymer chains3
Total molecular weight41467.81
Authors
Boichenko, I.,Albrecht, R.,Lupas, A.N.,Hernandez Alvarez, B.,Hartmann, M.D. (deposition date: 2017-07-14, release date: 2018-10-10)
Primary citation
Boichenko, I.,Bar, K.,Deiss, S.,Heim, C.,Albrecht, R.,Lupas, A.N.,Hernandez Alvarez, B.,Hartmann, M.D.
Chemical Ligand Space of Cereblon
Acs Omega, 2018
DOI: 10.1021/acsomega.8b00959
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21230 1.8% 10.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5oh7
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Molmil generated image of 5oh7
rotated about x axis by 90°
Molmil generated image of 5oh7
rotated about y axis by 90°
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