5OFY

Crystal structure of the D183N variant of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at pH 9.0. 2.8 Ang; internal aldimine with PLP in the active site

5OFY の概要

• エントリーDOI: 10.2210/pdb5ofy/pdb
• 関連するPDBエントリー: 5LUC
• 分子名称: Serine--pyruvate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total)
• 機能のキーワード: aminotransferase, detoxification, liver, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Peroxisome : P21549
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43397.10

構造登録者

Giardina, G.,Cutruzzola, F.,Borri Voltattorni, C.,Cellini, B.,Montioli, R. (登録日: 2017-07-11, 公開日: 2017-09-27, 最終更新日: 2024-01-17)

• 主引用文献: Giardina, G.,Paiardini, A.,Montioli, R.,Cellini, B.,Voltattorni, C.B.,Cutruzzola, F.; Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.; Sci Rep, 7:11704-11704, 2017; PubMed: 28916765; DOI: 10.1038/s41598-017-11948-w

実験手法

X-RAY DIFFRACTION (2.8 Å)