5OFV

Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-fluoro-2-methylbenzoic acid

Summary for 5OFV

Entry DOI	10.2210/pdb5ofv/pdb
Descriptor	D-3-phosphoglycerate dehydrogenase, 5-fluoranyl-2-methyl-benzoic acid (3 entities in total)
Functional Keywords	dehydrogenase, serine metabolism, fbdd, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	48175.64
Authors	Unterlass, J.E.,Basle, A.,Blackburn, T.J.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J. (deposition date: 2017-07-11, release date: 2017-08-16, Last modification date: 2024-05-08)
Primary citation	Unterlass, J.E.,Basle, A.,Blackburn, T.J.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J. Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9:13139-13153, 2018 Cited by PubMed: 29568346 DOI: 10.18632/oncotarget.11487 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation