Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5OFV

Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-fluoro-2-methylbenzoic acid

Summary for 5OFV
Entry DOI10.2210/pdb5ofv/pdb
DescriptorD-3-phosphoglycerate dehydrogenase, 5-fluoranyl-2-methyl-benzoic acid (3 entities in total)
Functional Keywordsdehydrogenase, serine metabolism, fbdd, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight48175.64
Authors
Unterlass, J.E.,Basle, A.,Blackburn, T.J.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J. (deposition date: 2017-07-11, release date: 2017-08-16, Last modification date: 2024-05-08)
Primary citationUnterlass, J.E.,Basle, A.,Blackburn, T.J.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J.
Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
Oncotarget, 9:13139-13153, 2018
Cited by
PubMed: 29568346
DOI: 10.18632/oncotarget.11487
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

221051

数据于2024-06-12公开中

PDB statisticsPDBj update infoContact PDBjnumon