5OF9

Crystal structure of human MORC2 (residues 1-603)

5OF9 の概要

• エントリーDOI: 10.2210/pdb5of9/pdb
• 分子名称: MORC family CW-type zinc finger protein 2, ZINC ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• 機能のキーワード: ghkl atpase, chromatin remodeler, epigenetic silencing, transcriptional repressor, coiled-coil, cw domain, dna binding protein, charcot-marie-tooth disease, spinal muscular atrophy, nuclear protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q9Y6X9
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 141229.82

構造登録者

Douse, C.H.,Shamin, M.,Modis, Y. (登録日: 2017-07-10, 公開日: 2018-02-14, 最終更新日: 2024-01-17)

• 主引用文献: Douse, C.H.,Bloor, S.,Liu, Y.,Shamin, M.,Tchasovnikarova, I.A.,Timms, R.T.,Lehner, P.J.,Modis, Y.; Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.; Nat Commun, 9:651-651, 2018; PubMed: 29440755; DOI: 10.1038/s41467-018-03045-x

実験手法

X-RAY DIFFRACTION (1.807 Å)