5OF0

X-ray structure of human glutamate carboxypeptidase II (GCPII), the E424M inactive mutant, in complex with a inhibitor CFBzOG

5OF0 の概要

• エントリーDOI: 10.2210/pdb5of0/pdb
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen; urea based inhibitor, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 83639.71

構造登録者

Novakova, Z.,Motlova, L.,Barinka, C. (登録日: 2017-07-10, 公開日: 2018-08-01, 最終更新日: 2024-10-09)

主引用文献

Nakajima, R.,Novakova, Z.,Tueckmantel, W.,Motlova, L.,Barinka, C.,Kozikowski, A.P.
2-Aminoadipic Acid-C(O)-Glutamate Based Prostate-Specific Membrane Antigen Ligands for Potential Use as Theranostics.
ACS Med Chem Lett, 9:1099-1104, 2018

PubMed Abstract: The design and synthesis of prostate specific membrane antigen (PSMA) ligands derived from 2-aminoadipic acid, a building block that has not previously been used to construct PSMA ligands, are reported. The effects of both the linker length and of an N-substituent of our PSMA ligands were probed, and X-ray structures of five of these ligands bound to PSMA were obtained. Among the ligands disclosed herein, showed the highest inhibitory activity for PSMA. As ligand can readily be radiolabeled since its fluorine atom is adjacent to the nitrogen atom of its pyridine ring, the use of this and related compounds as theranostics can be pursued.

PubMed: 30429952
DOI: 10.1021/acsmedchemlett.8b00318

実験手法

X-RAY DIFFRACTION (1.48 Å)