5OF0

X-ray structure of human glutamate carboxypeptidase II (GCPII), the E424M inactive mutant, in complex with a inhibitor CFBzOG

5OF0 の概要

• エントリーDOI: 10.2210/pdb5of0/pdb
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen; urea based inhibitor, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 83639.71

構造登録者

Novakova, Z.,Motlova, L.,Barinka, C. (登録日: 2017-07-10, 公開日: 2018-08-01, 最終更新日: 2024-01-17)

• 主引用文献: Nakajima, R.,Novakova, Z.,Tueckmantel, W.,Motlova, L.,Barinka, C.,Kozikowski, A.P.; 2-Aminoadipic Acid-C(O)-Glutamate Based Prostate-Specific Membrane Antigen Ligands for Potential Use as Theranostics.; ACS Med Chem Lett, 9:1099-1104, 2018; PubMed: 30429952; DOI: 10.1021/acsmedchemlett.8b00318

実験手法

X-RAY DIFFRACTION (1.48 Å)