5OEQ
Mycobacterium tuberculosis DprE1 in complex with inhibitor TCA020
Summary for 5OEQ
Entry DOI | 10.2210/pdb5oeq/pdb |
Related | 4KW5 5OEL 5OEP |
Descriptor | Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, ~{N}-[3-(pyrimidin-2-ylcarbamoyl)thiophen-2-yl]-[1,3]thiazolo[4,5-c]pyridine-2-carboxamide, ... (5 entities in total) |
Functional Keywords | fad-containing oxidoreductase decaprenylphosphoarabinose synthesis, oxidoreductase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 2 |
Total formula weight | 106102.29 |
Authors | Futterer, K.,Batt, S.M.,Besra, G.S. (deposition date: 2017-07-09, release date: 2018-05-16, Last modification date: 2024-01-17) |
Primary citation | Liu, R.,Lyu, X.,Batt, S.M.,Hsu, M.H.,Harbut, M.B.,Vilcheze, C.,Cheng, B.,Ajayi, K.,Yang, B.,Yang, Y.,Guo, H.,Lin, C.,Gan, F.,Wang, C.,Franzblau, S.G.,Jacobs, W.R.,Besra, G.S.,Johnson, E.F.,Petrassi, M.,Chatterjee, A.K.,Futterer, K.,Wang, F. Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes. Angew. Chem. Int. Ed. Engl., 56:13011-13015, 2017 Cited by PubMed: 28815830DOI: 10.1002/anie.201707324 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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