5OEK

Putative active dimeric state of GHR transmembrane domain

5OEK の概要

• エントリーDOI: 10.2210/pdb5oek/pdb
• NMR情報: BMRB: 34160
• 分子名称: Growth hormone receptor (1 entity in total)
• 機能のキーワード: dimer, ghr, growth hormone receptor, homodimer, human, receptor, transmembrane domain, tyrosine kinase, membrane protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 10290.26

構造登録者

Lesovoy, D.M.,Bocharov, E.V.,Bocharova, O.V.,Urban, A.S.,Arseniev, A.S. (登録日: 2017-07-08, 公開日: 2018-04-11, 最終更新日: 2024-07-03)

主引用文献

Bocharov, E.V.,Lesovoy, D.M.,Bocharova, O.V.,Urban, A.S.,Pavlov, K.V.,Volynsky, P.E.,Efremov, R.G.,Arseniev, A.S.
Structural basis of the signal transduction via transmembrane domain of the human growth hormone receptor.
Biochim. Biophys. Acta, 1862:1410-1420, 2018

PubMed Abstract: Prior studies of the human growth hormone receptor (GHR) revealed a distinct role of spatial rearrangements of its dimeric transmembrane domain in signal transduction across membrane. Detailed structural information obtained in the present study allowed elucidating the bases of such rearrangement and provided novel insights into receptor functioning.

PubMed: 29571748
DOI: 10.1016/j.bbagen.2018.03.022

実験手法

SOLUTION NMR