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5OCA

PCSK9:Fab Complex with Dextran Sulfate

Summary for 5OCA
Entry DOI10.2210/pdb5oca/pdb
Related PRD IDPRD_900071
DescriptorProprotein convertase subtilisin/kexin type 9, Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, ... (7 entities in total)
Functional Keywordshydrolase, protein fab complex, autocatalytic cleavage, cholesterol metabolism, disease mutation, disulfide bond, glycoprotein, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, hydrolase-immune system complex
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight120341.24
Authors
Thirup, S.S.,Vilstrup, J.P. (deposition date: 2017-06-30, release date: 2017-09-20, Last modification date: 2020-07-29)
Primary citationGustafsen, C.,Olsen, D.,Vilstrup, J.,Lund, S.,Reinhardt, A.,Wellner, N.,Larsen, T.,Andersen, C.B.F.,Weyer, K.,Li, J.P.,Seeberger, P.H.,Thirup, S.,Madsen, P.,Glerup, S.
Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.
Nat Commun, 8:503-503, 2017
Cited by
PubMed: 28894089
DOI: 10.1038/s41467-017-00568-7
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

數據於2024-03-27公開中

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