5OCA

PCSK9:Fab Complex with Dextran Sulfate

Summary for 5OCA

DescriptorProprotein convertase subtilisin/kexin type 9, Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, ... (7 entities in total)
Functional Keywordshydrolase, protein fab complex, autocatalytic cleavage, cholesterol metabolism, disease mutation, disulfide bond, glycoprotein, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, hydrolase-immune system complex
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm Q8NBP7 Q8NBP7
Total number of polymer chains4
Total molecular weight120341.24
Authors
Thirup, S.S.,Vilstrup, J.P. (deposition date: 2017-06-30, release date: 2017-09-20)
Primary citation
Gustafsen, C.,Olsen, D.,Vilstrup, J.,Lund, S.,Reinhardt, A.,Wellner, N.,Larsen, T.,Andersen, C.B.F.,Weyer, K.,Li, J.P.,Seeberger, P.H.,Thirup, S.,Madsen, P.,Glerup, S.
Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.
Nat Commun, 8:503-503, 2017
PubMed: 28894089 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-017-00568-7
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19470.1%1.8%8.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution