5OCA
PCSK9:Fab Complex with Dextran Sulfate
Summary for 5OCA
Entry DOI | 10.2210/pdb5oca/pdb |
Related PRD ID | PRD_900071 |
Descriptor | Proprotein convertase subtilisin/kexin type 9, Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, ... (7 entities in total) |
Functional Keywords | hydrolase, protein fab complex, autocatalytic cleavage, cholesterol metabolism, disease mutation, disulfide bond, glycoprotein, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, hydrolase-immune system complex |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 120341.24 |
Authors | Thirup, S.S.,Vilstrup, J.P. (deposition date: 2017-06-30, release date: 2017-09-20, Last modification date: 2020-07-29) |
Primary citation | Gustafsen, C.,Olsen, D.,Vilstrup, J.,Lund, S.,Reinhardt, A.,Wellner, N.,Larsen, T.,Andersen, C.B.F.,Weyer, K.,Li, J.P.,Seeberger, P.H.,Thirup, S.,Madsen, P.,Glerup, S. Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. Nat Commun, 8:503-503, 2017 Cited by PubMed: 28894089DOI: 10.1038/s41467-017-00568-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report