5OCA

PCSK9:Fab Complex with Dextran Sulfate

5OCA の概要

• エントリーDOI: 10.2210/pdb5oca/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900071
• 分子名称: Proprotein convertase subtilisin/kexin type 9, Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, ... (7 entities in total)
• 機能のキーワード: hydrolase, protein fab complex, autocatalytic cleavage, cholesterol metabolism, disease mutation, disulfide bond, glycoprotein, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, hydrolase-immune system complex
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 120341.24

構造登録者

Thirup, S.S.,Vilstrup, J.P. (登録日: 2017-06-30, 公開日: 2017-09-20, 最終更新日: 2020-07-29)

• 主引用文献: Gustafsen, C.,Olsen, D.,Vilstrup, J.,Lund, S.,Reinhardt, A.,Wellner, N.,Larsen, T.,Andersen, C.B.F.,Weyer, K.,Li, J.P.,Seeberger, P.H.,Thirup, S.,Madsen, P.,Glerup, S.; Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.; Nat Commun, 8:503-503, 2017; PubMed: 28894089; DOI: 10.1038/s41467-017-00568-7

実験手法

X-RAY DIFFRACTION (2.3 Å)