5OBR

Aurora A kinase in complex with 2-(3-chloro-5-fluorophenyl)quinoline-4-carboxylic acid and JNJ-7706621

5OBR の概要

• エントリーDOI: 10.2210/pdb5obr/pdb
• 分子名称: Aurora kinase A, 2-(3-chloranyl-5-fluoranyl-phenyl)quinoline-4-carboxylic acid, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, ... (5 entities in total)
• 機能のキーワード: inhibitor, kinase, allostery, protein-protein interface, cell cycle
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32176.51

構造登録者

Rossmann, M.,Janecek, M.,Hyvonen, M. (登録日: 2017-06-29, 公開日: 2017-08-09, 最終更新日: 2024-05-08)

• 主引用文献: Cole, D.J.,Janecek, M.,Stokes, J.E.,Rossmann, M.,Faver, J.C.,McKenzie, G.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R.,Huggins, D.J.,Jorgensen, W.L.; Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.; Chem. Commun. (Camb.), 53:9372-9375, 2017; PubMed: 28787041; DOI: 10.1039/c7cc05379g

実験手法

X-RAY DIFFRACTION (2.62 Å)