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5O9H

Crystal structure of thermostabilised human C5a anaphylatoxin chemotactic receptor 1 (C5aR) in complex with NDT9513727

Summary for 5O9H
Entry DOI10.2210/pdb5o9h/pdb
DescriptorC5a anaphylatoxin chemotactic receptor 1, 1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine, L(+)-TARTARIC ACID, ... (6 entities in total)
Functional Keywordsgpcr, 7tm, signalling protein, membrane protein
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Multi-pass membrane protein : P21730
Total number of polymer chains2
Total formula weight82313.35
Authors
Robertson, N.,Rappas, M.,Dore, A.S.,Brown, J.,Bottegoni, G.,Koglin, M.,Cansfield, J.,Jazayeri, A.,Cooke, R.M.,Marshall, F.H. (deposition date: 2017-06-19, release date: 2018-01-10, Last modification date: 2024-01-17)
Primary citationRobertson, N.,Rappas, M.,Dore, A.S.,Brown, J.,Bottegoni, G.,Koglin, M.,Cansfield, J.,Jazayeri, A.,Cooke, R.M.,Marshall, F.H.
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727.
Nature, 553:111-114, 2018
Cited by
PubMed: 29300009
DOI: 10.1038/nature25025
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

數據於2024-03-27公開中

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