5O9H
Crystal structure of thermostabilised human C5a anaphylatoxin chemotactic receptor 1 (C5aR) in complex with NDT9513727
Summary for 5O9H
Entry DOI | 10.2210/pdb5o9h/pdb |
Descriptor | C5a anaphylatoxin chemotactic receptor 1, 1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine, L(+)-TARTARIC ACID, ... (6 entities in total) |
Functional Keywords | gpcr, 7tm, signalling protein, membrane protein |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Multi-pass membrane protein : P21730 |
Total number of polymer chains | 2 |
Total formula weight | 82313.35 |
Authors | Robertson, N.,Rappas, M.,Dore, A.S.,Brown, J.,Bottegoni, G.,Koglin, M.,Cansfield, J.,Jazayeri, A.,Cooke, R.M.,Marshall, F.H. (deposition date: 2017-06-19, release date: 2018-01-10, Last modification date: 2024-01-17) |
Primary citation | Robertson, N.,Rappas, M.,Dore, A.S.,Brown, J.,Bottegoni, G.,Koglin, M.,Cansfield, J.,Jazayeri, A.,Cooke, R.M.,Marshall, F.H. Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727. Nature, 553:111-114, 2018 Cited by PubMed: 29300009DOI: 10.1038/nature25025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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