5O9H

Crystal structure of thermostabilised human C5a anaphylatoxin chemotactic receptor 1 (C5aR) in complex with NDT9513727

5O9H の概要

• エントリーDOI: 10.2210/pdb5o9h/pdb
• 分子名称: C5a anaphylatoxin chemotactic receptor 1, 1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine, L(+)-TARTARIC ACID, ... (6 entities in total)
• 機能のキーワード: gpcr, 7tm, signalling protein, membrane protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : P21730
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82313.35

構造登録者

Robertson, N.,Rappas, M.,Dore, A.S.,Brown, J.,Bottegoni, G.,Koglin, M.,Cansfield, J.,Jazayeri, A.,Cooke, R.M.,Marshall, F.H. (登録日: 2017-06-19, 公開日: 2018-01-10, 最終更新日: 2024-01-17)

• 主引用文献: Robertson, N.,Rappas, M.,Dore, A.S.,Brown, J.,Bottegoni, G.,Koglin, M.,Cansfield, J.,Jazayeri, A.,Cooke, R.M.,Marshall, F.H.; Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727.; Nature, 553:111-114, 2018; PubMed: 29300009; DOI: 10.1038/nature25025

実験手法

X-RAY DIFFRACTION (2.7 Å)