5O91

Crystal structure of human Mps1 (TTK) C604W mutant in complex with Cpd-5

5O91 の概要

• エントリーDOI: 10.2210/pdb5o91/pdb
• 分子名称: Dual specificity protein kinase TTK, ~{N}-(2,6-diethylphenyl)-8-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: mps1, ttk, kinase, inhibitor, cpd-5, mutant, c604w, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36841.11

構造登録者

Hiruma, Y.,Joosten, R.P.,Perrakis, A. (登録日: 2017-06-15, 公開日: 2017-07-26, 最終更新日: 2024-01-17)

• 主引用文献: Hiruma, Y.,Koch, A.,Hazraty, N.,Tsakou, F.,Medema, R.H.,Joosten, R.P.,Perrakis, A.; Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.; J. Biol. Chem., 292:14496-14504, 2017; PubMed: 28726638; DOI: 10.1074/jbc.M117.783555

実験手法

X-RAY DIFFRACTION (3.2 Å)