5O8U
Covalent Inhibitor 4b bound to the Lipid Pocket of p38alpha Mutant S252C
Summary for 5O8U
Entry DOI | 10.2210/pdb5o8u/pdb |
Descriptor | Mitogen-activated protein kinase 14, 4-[3-[7-azanyl-4-(2-phenylethylamino)quinazolin-2-yl]phenyl]butan-2-one (3 entities in total) |
Functional Keywords | kinase, small molecule, lipid pocket, p38, covalent, mutant, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41769.77 |
Authors | Buehrmann, M.,Rauh, D. (deposition date: 2017-06-14, release date: 2017-09-06, Last modification date: 2024-01-17) |
Primary citation | Buhrmann, M.,Hardick, J.,Weisner, J.,Quambusch, L.,Rauh, D. Covalent Lipid Pocket Ligands Targeting p38 alpha MAPK Mutants. Angew. Chem. Int. Ed. Engl., 56:13232-13236, 2017 Cited by PubMed: 28834017DOI: 10.1002/anie.201706345 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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