5O83
Discovery of CDZ173 (leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors
Summary for 5O83
| Entry DOI | 10.2210/pdb5o83/pdb |
| Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Leniolisib (3 entities in total) |
| Functional Keywords | kinase, transferase, pi3k delta, inhibitor |
| Biological source | Mus musculus (Mouse) |
| Total number of polymer chains | 1 |
| Total formula weight | 108402.25 |
| Authors | Gutmann, S.,Rummel, G.,Shrestha, B. (deposition date: 2017-06-12, release date: 2017-09-20, Last modification date: 2019-10-16) |
| Primary citation | Hoegenauer, K.,Soldermann, N.,Zecri, F.,Strang, R.S.,Graveleau, N.,Wolf, R.M.,Cooke, N.G.,Smith, A.B.,Hollingworth, G.J.,Blanz, J.,Gutmann, S.,Rummel, G.,Littlewood-Evans, A.,Burkhart, C. Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors. ACS Med Chem Lett, 8:975-980, 2017 Cited by PubMed: 28947947DOI: 10.1021/acsmedchemlett.7b00293 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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