5O83

Discovery of CDZ173 (leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors

5O83 の概要

• エントリーDOI: 10.2210/pdb5o83/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Leniolisib (3 entities in total)
• 機能のキーワード: kinase, transferase, pi3k delta, inhibitor
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 108402.25

構造登録者

Gutmann, S.,Rummel, G.,Shrestha, B. (登録日: 2017-06-12, 公開日: 2017-09-20, 最終更新日: 2024-05-08)

• 主引用文献: Hoegenauer, K.,Soldermann, N.,Zecri, F.,Strang, R.S.,Graveleau, N.,Wolf, R.M.,Cooke, N.G.,Smith, A.B.,Hollingworth, G.J.,Blanz, J.,Gutmann, S.,Rummel, G.,Littlewood-Evans, A.,Burkhart, C.; Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.; ACS Med Chem Lett, 8:975-980, 2017; PubMed: 28947947; DOI: 10.1021/acsmedchemlett.7b00293

実験手法

X-RAY DIFFRACTION (2.9 Å)