5O7A

Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin

5O7A の概要

• エントリーDOI: 10.2210/pdb5o7a/pdb
• 分子名称: Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... (10 entities in total)
• 機能のキーワード: microtubules, tubulin, colchicine, quinolin-6-yloxyacetamides, motor protein
• 由来する生物種: Rattus norvegicus (Norway Rat); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 264877.29

構造登録者

Sharma, A.,Olieric, N.,Steinmetz, M.O. (登録日: 2017-06-08, 公開日: 2017-07-05)

• 主引用文献: Sharma, A.,Saez-Calvo, G.,Olieric, N.,de Asis Balaguer, F.,Barasoain, I.,Lamberth, C.,Diaz, J.F.,Steinmetz, M.O.; Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.; Int J Mol Sci, 18:-, 2017; PubMed: 28640209; DOI: 10.3390/ijms18071336

実験手法

X-RAY DIFFRACTION (2.495 Å)