5O5M

Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and RKp117

Summary for 5O5M

Entry DOI	10.2210/pdb5o5m/pdb
Descriptor	cAMP-dependent protein kinase catalytic subunit alpha, RKp120, [2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)methyl]phenyl]boronic acid, ... (5 entities in total)
Functional Keywords	complex, peptidic ligand, transferase
Biological source	Cricetulus griseus (Chinese hamster) More
Total number of polymer chains	2
Total formula weight	43600.66
Authors	Mueller, J.M.,Heine, A.,Klebe, G. (deposition date: 2017-06-02, release date: 2018-06-13, Last modification date: 2024-10-16)
Primary citation	Mueller, J.M.,Kirschner, R.,Geyer, A.,Klebe, G. Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019 Cited by DOI: 10.1021/acsomega.8b02364 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.583 Å)

Structure validation